CLASS participates in projects related to multiphysics and multidisciplinary computation, particularly those that span departments at Texas A&M University or multiple research institutions, including both universities and national laboratories.
CLASS has been associated with several PSAAP centers funded by the National Nuclear Security Administration under the Predictive Science Academic Alliance Program. Two of the PSAAP-I centers (PECOS and CRASH) were led by the University of Texas and the University of Michigan, respectively, with participation by CLASS researchers. The PSAAP-II Center for Exascale Radiation Transport was led by CLASS. All of these PSAAP centers were multidisciplinary and multi-institutional.
CLASS is currently associated with a major multidisciplinary project funded by Lawrence Livermore National Laboratory. It is called the SSSP (Support of Stockpile Stewardship Project), as well as other smaller projects that are either multidisciplinary or use CLASS software and/or staff.