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CLASS participates in projects related to multiphysics and multidisciplinary computation, particularly those that span departments at Texas A&M University or multiple research institutions, including both universities and national laboratories.

CLASS is currently associated with three major projects. All three are multidisciplinary and two are multi-institutional.

CLASS also oversees administration of the Center for Exascale Radiation Transport (CERT), a multidisciplinary, multi-institutional center created at Texas A&M University through a research grant from the  National Nuclear Security Agency (NNSA) under the  Predictive Science Academic Alliance Program (PSAAP-II).